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MYP_093320
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Basic Information
Scolopendin 2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
16 amino acids
C81H141N27O18
Standard
Sequence
AGLQFPVGRIGRLLRK
Physicochemical Analysis
1781.16 Da
12.00
3.79
3.61
0.2372
0.06
0.85
-0.06
55.84
121.88
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
745.84
-5.64
27.0
22.0
60.0
126.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0222131 VERIFIED: YES
Provenance & Taxonomy
Chinese red-headed centipede [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
C. parapsilosis ATCC 22019
12.5 μM
MIC
PaperScolopendin 2, a cationic antimicrobial peptide from centipede, and its membrane-active mechanism.
RECORD: Rec_0273012 VERIFIED: YES
Provenance & Taxonomy
Chinese red-headed centipede [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa ATCC 27853 including three resistant strains
6.3-12.5 μM
MIC
PaperScolopendin 2, a cationic antimicrobial peptide from centipede, and its membrane-active mechanism.
RECORD: Rec_0287023 VERIFIED: YES
Provenance & Taxonomy
Chinese red-headed centipede [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
T. rubrum KCTC 6345
6.3 μM
MIC
PaperScolopendin 2, a cationic antimicrobial peptide from centipede, and its membrane-active mechanism.
RECORD: Rec_0298104 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 31.2%, E 0.0%, T 50.0%, C 18.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0304068 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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