Peptide Database

Peptide NameDefensin alpha 4 (Corticostatin HP-4) (HNP-4) (HP-4) (Neutrophil defensin 4)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antimicrobial ▸ Antifungal ▸ Fungicidal activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length97 amino acids

Chemical FormulaC451H744N136O136S8

DescriptionStandard

        MRIIAILAAILLVALQVRAGPLQARGDEAPGQEQRGPEDQDISISFAWDKSSALQVSGSTRGMVCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD
    

Molecular Weight10504.08 Da

Isoelectric Point (pI)8.30

Net Charge (pH 7.0)1.46

Net Charge (pH 7.4) 1.14

Charge Density (pH 7.0) 0.0150

GRAVY Index0.19

Hydrophobic Moment 0.59

Boman Index0.04

Instability Index48.08

Aliphatic Index 97.53

Aromaticity 0.0515

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4391.68

LogP -48.69

H-bond Donors 162.0

H-bond Acceptors 146.0

Rotatable Bonds 350.0

Heavy Atoms 731.0

Ring Count 9.0

Amide Bonds 103.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0011712 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0042420 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetB. anthracis (Gram-positive)

RECORD: Rec_0074401 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetS. faecalis (Gram-positive)

RECORD: Rec_0104184 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0297359 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetB. cereus (Gram-positive)

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