‹ ›
MYP_093289
← PREVIOUS NEXT → BACK
Basic Information
YIK(625-656)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
32 amino acids
C184H292N44O58S
Standard
Sequence
EMTWEEWEKKIEEYIKKIEEILKKSQNQQIDL
Physicochemical Analysis
4080.61 Da
4.73
-3.15
-3.34
-0.0984
-1.30
0.75
-0.24
68.53
85.31
0.0938
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1721.87
-9.89
57.0
56.0
149.0
287.0
5.0
35.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0002776 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Fusion inhibition
inhibition of cell-cell fusion between H9/IIIB cells and MT-2 cells
0.00112 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperA Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life. | Su S, Rasquinha G, Du L, Wang Q, Xu W, Li W, Lu L, Jiang S. | Molecules. 2019 Mar 21;24(6):1134. | DOI:10.3390/molecules24061134 | PMID:30901967 PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0024100 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1IIIB(X4 virus):inhibition of virus infection in MT-2 cells
0.000275 μM
IC50
PaperPubMed PMID: 30901967 PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0025261 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
MT-2 or M7 cells at the concentrations as high as 8 μM
PaperPubMed PMID: 30901967 PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0061816 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 30901967 PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0075627 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 D36G/V38A
PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
1 2 3 ... 5 NEXT LAST
Showing 5 records on this page · Page 1 of 5