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MYP_093265
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Basic Information
Calcitonin-1
Hormonal / Endocrine ▸ Hormone peptide
Regulatory peptide ▸ Biological modulation
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
32 amino acids
C145H241N43O49S2
Standard
Sequence
CSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP
Physicochemical Analysis
3434.85 Da
8.86
1.83
1.54
0.0571
-0.54
0.60
-0.06
17.84
70.00
0.0312
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1502.42
-21.46
54.0
54.0
112.0
239.0
4.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0032287 VERIFIED: YES
Provenance & Taxonomy
Oncorhynchus keta [Animal]
calcitonin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
1-7
Bio-Activity Profile
Hormone calcitonin family
PaperPDB 2GLG structural record; NMR; chain A; residues 1-32
RECORD: Rec_0101943 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Insulin
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone replacement Enzyme replacement
0.83-1.33 hours
Evidence URLhttps://patents.google.com/patent/US5733569/en PatentUS5733569
RECORD: Rec_0131185 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Calcitonin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
1-7
Bio-Activity Profile
Calcitropic Hormone reduce blood calcium
LC-ESI-MS
Rat kidney homogenates, in vitro; 790.8 s
PMID18972837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18972837/
RECORD: Rec_0197017 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Calcitonin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
1-7
Bio-Activity Profile
Bone metabolism regulator Anti-resorptive Calcitonin receptor agonist
0.83-1.33 h
PaperPubMed-linked source references: PMID:25860966; PMID:24708057; PMID:24357414; PMID:24252061; PMID:22001608; PMID:20946924; PMID:18704953; PMID:18023905; PMID:17207880 PMID25860966;24708057;24357414;24252061;22001608;20946924;18704953;18023905;17207880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25860966/ PatentUS6440392
RECORD: Rec_0218842 VERIFIED: YES
Provenance & Taxonomy
Oncorhynchus keta [Animal]
Calcitonin
8018
Structure & Mods
linear peptide with reported disulfide constraint [Linear]
canonical L-amino-acid peptide [L]
Amidation
1-7
Bio-Activity Profile
Hormone Endocrine Receptor modulation
Experimental: 13.18 minutes; /790.8 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PMID18972837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18972837/
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