Peptide Database

Peptide NameSLAY-screened peptide P3889

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC89H155N29O28S3

DescriptionStandard

        LTHLSVSPNRISARCTCLTC
    

Molecular Weight2175.56 Da

Isoelectric Point (pI)8.73

Net Charge (pH 7.0)1.82

Net Charge (pH 7.4) 1.52

Charge Density (pH 7.0) 0.0909

GRAVY Index0.38

Hydrophobic Moment 0.41

Boman Index0.02

Instability Index57.40

Aliphatic Index 97.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 924.38

LogP -12.75

H-bond Donors 37.0

H-bond Acceptors 34.0

Rotatable Bonds 68.0

Heavy Atoms 149.0

Ring Count 2.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0427149 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/