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MYP_093045
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HPV
Antiviral ▸ Antiviral mechanism ▸ Pseudovirus inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
49 amino acids
C244H403N85O66S5
Standard
Sequence
GRRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQA
Physicochemical Analysis
5743.67 Da
11.24
8.72
8.45
0.1780
-0.85
0.60
-0.34
93.55
53.67
0.0612
11000.00
11250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2507.18
-29.41
93.0
80.0
190.0
400.0
9.0
55.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015434 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0057522 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Lactoferrin-derived
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human papillomavirus (Virus entry); HaCaT
16 μM
Western blotting
PaperThe anti-papillomavirus activity of human and bovine lactoferricin. | Mistry N, Drobni P, Naslund J, Sunkari VG, Jenssen H, Evander M. | Antiviral Res. 2007 | PMID:17481742 PMID17481742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17481742/
RECORD: Rec_0080371 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
10-46, 20-37
Bio-Activity Profile
Antimicrobial Antiviral
human papillomavirus(HPV):inhibition of pseudovirus infection in C33A cells
0.32±0.18 μM
IC50
PaperPubMed PMID: 17481742 PMID17481742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17481742/
RECORD: Rec_0237867 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
10-46, 20-37
Disulfide bonds between Cys10 and Cys46, Cys20 and Cys37.
Bio-Activity Profile
Antiviral Anti-HPV Pseudovirus inhibition
Human papillomavirus(HPV) | C33A cells
0.32±0.18 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperThe anti-papillomavirus activity of human and bovine lactoferricin. | Mistry N, Drobni P, Näslund J, Sunkari VG, Jenssen H, Evander M. | Antiviral Res. 2007 Sep;75(3):258-65. | DOI:10.1016/j.antiviral.2007.03.012 | PMID:17481742 PMID17481742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17481742/
RECORD: Rec_0314831 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Bos taurus [Animal]
9606; 9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
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