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MYP_092975
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
25 amino acids
C129H215N47O33S4
Standard
Sequence
RSVCRQIKICRRRGGCYYKCTNRPY
Physicochemical Analysis
3080.64 Da
10.22
7.72
7.45
0.3086
-1.06
0.66
-0.53
95.12
42.80
0.1200
4470.00
4720.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1363.70
-15.53
56.0
45.0
102.0
213.0
4.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0333174 VERIFIED: YES
Provenance & Taxonomy
Androctonus australis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas syringae phaseoli
1.5-3 μM
MIC
PMID8939880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/
RECORD: Rec_0337237 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperHetru C., Letellier L., Oren Z., Hoffmann J.A., Shai Y.;. "Androctonin, a novel antimicrobial peptide from scorpion Androctonus australis: solution structure and molecular dynamics simulations in the presence of a lipid monolayer."; J. Biomol. Struct. Dyn. 17:367-380. Evidence URLhttps://www.uniprot.org/uniprotkb/ANDT_ANDAU/entry
RECORD: Rec_0339184 VERIFIED: YES
Provenance & Taxonomy
Androctonus australis [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-20; 10-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Verticilium toreilis
2-4 μM
MIC
PaperPubMed PMID: 8939880 | PubMed PMID: 10563585 | Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID8939880;10563585;10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/
RECORD: Rec_0343779 VERIFIED: YES
Provenance & Taxonomy
Androctonus australis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Fusarium culmorum
3-6 μM
MIC
PMID8939880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/
RECORD: Rec_0358854 VERIFIED: YES
Provenance & Taxonomy
Androctonus australis [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-20; 10-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
15-30 μM
MIC
PaperPubMed PMID: 8939880 | PubMed PMID: 10563585 | Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID8939880;10563585;10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/
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