Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC129H215N47O33S4

DescriptionStandard

        RSVCRQIKICRRRGGCYYKCTNRPY
    

Molecular Weight3080.64 Da

Isoelectric Point (pI)10.22

Net Charge (pH 7.0)7.72

Net Charge (pH 7.4) 7.45

Charge Density (pH 7.0) 0.3086

GRAVY Index-1.06

Hydrophobic Moment 0.66

Boman Index-0.53

Instability Index95.12

Aliphatic Index 42.80

Aromaticity 0.1200

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4720.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1363.70

LogP -15.53

H-bond Donors 56.0

H-bond Acceptors 45.0

Rotatable Bonds 102.0

Heavy Atoms 213.0

Ring Count 4.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0170101 VERIFIED: YES

Provenance & Taxonomy

OrganismAndroctonus australis [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide4-20; 10-16

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetFusarium oxysporum L

PaperPubMed PMID: 8939880 | PubMed PMID: 10563585 | Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID8939880;10563585;10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/

RECORD: Rec_0175065 VERIFIED: YES

Provenance & Taxonomy

OrganismAndroctonus australis [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide4-20; 10-16

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetAerococcus viridans

Activity0.3-0.6 μM

MethodMIC

PaperPubMed PMID: 8939880 | PubMed PMID: 10563585 | Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID8939880;10563585;10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/

RECORD: Rec_0178181 VERIFIED: YES

Provenance & Taxonomy

OrganismAndroctonus australis [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide4-20; 10-16

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetXanthomonas vesicatoria B229RI

Activity1.5-3 μM

MethodMIC

PaperPubMed PMID: 8939880 | PubMed PMID: 10563585 | Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID8939880;10563585;10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/

RECORD: Rec_0186675 VERIFIED: YES

Provenance & Taxonomy

OrganismAndroctonus australis [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide4-20; 10-16

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targetcompestris

Activity3-6 μM

MethodMIC

PaperPubMed PMID: 8939880 | PubMed PMID: 10563585 | Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID8939880;10563585;10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/

RECORD: Rec_0191595 VERIFIED: YES

Provenance & Taxonomy

OrganismAndroctonus australis [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide4-20; 10-16

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetPseudomonas syringae phaseoli

Activity1.5-3 μM

MethodMIC

PaperPubMed PMID: 8939880 | PubMed PMID: 10563585 | Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID8939880;10563585;10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/

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