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MYP_092906
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Basic Information
r8-BidBH3Alt
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C141H254N66O39S
Standard
Sequence
RRRRRRRRGEDIIRNIARHAAQVGASMDR
Physicochemical Analysis
3530.01 Da
12.00
7.85
7.60
0.2708
-1.55
0.90
-0.80
164.02
64.14
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1806.01
-23.33
70.0
49.0
126.0
247.0
1.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0336308 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
rrrrrrrr=D-isomer homopolymer of eight arginine residues
Bio-Activity Profile
Antimicrobial Anticancer
IMR-5 (2% apoptosis at 50 μM)
PaperPubMed PMID: 16568093 PMID16568093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16568093/
RECORD: Rec_0337448 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Anticancer
IMR5
10 μM
Concentration response
PaperBH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma PMID16568093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16568093/
RECORD: Rec_0347604 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Anticancer
NB69
10 μM
Concentration response
PaperBH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma PMID16568093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16568093/
RECORD: Rec_0354075 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
rrrrrrrr=D-isomer homopolymer of eight arginine residues
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 16568093 PMID16568093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16568093/
RECORD: Rec_0363842 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
rrrrrrrr=D-isomer homopolymer of eight arginine residues
Bio-Activity Profile
Antimicrobial Anticancer
(5% apoptosis at 50 μM)
PaperPubMed PMID: 16568093 PMID16568093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16568093/
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