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MYP_092836
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Standard
3 amino acids
C11H17N5O5
Standard
Sequence
GHS
Physicochemical Analysis
299.28 Da
6.74
-0.15
-0.41
-0.0509
-1.47
0.26
-0.03
6.67
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
170.43
-3.04
6.0
6.0
8.0
21.0
1.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022612 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperHe R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.. Glycinyl-histidinyl-serine (GHS), a novel rapeseed protein-derived peptide has blood pressure-lowering effect in spontaneously hypertensive rats. J. Agric. Food Chem., 61, 8396-8402, 2013.
RECORD: Rec_0070041 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
PaperHe R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.. Glycinyl-histidinyl-serine (GHS), a novel rapeseed protein-derived peptide has blood pressure-lowering effect in spontaneously hypertensive rats. J. Agric. Food Chem., 61, 8396-8402, 2013.
RECORD: Rec_0088277 VERIFIED: NO
Provenance & Taxonomy
Actinopterygii [Animal]
7898
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperReview on the angiotensin-I-converting enzyme (ACE) inhibitor peptides from marine proteins PMID23271625 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23271625/
RECORD: Rec_0184353 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
ACE-inhibitory peptide
3708
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
510-530 μg/mL
IC50
PaperGlycinyl-Histidinyl-Serine (GHS), a Novel Rapeseed Protein-Derived Peptide Has Blood Pressure-Lowering Effect in Spontaneously Hypertensive Rats PMID23919612 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23919612/
RECORD: Rec_0296935 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
ACE-inhibitory peptide
3708
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
17.29 mmHg
SBP decrease
PaperGlycinyl-Histidinyl-Serine (GHS), a Novel Rapeseed Protein-Derived Peptide Has Blood Pressure-Lowering Effect in Spontaneously Hypertensive Rats PMID23919612 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23919612/
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