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MYP_092804
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Basic Information
PN159 (SEQ ID NO: 13)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Virucidal activity
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C90H169N23O19
Standard
Sequence
KLALKLALKALKAALKLA
Physicochemical Analysis
1877.45 Da
10.60
4.76
4.54
0.2642
0.99
0.57
0.20
-23.57
185.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
688.12
-1.27
24.0
24.0
69.0
132.0
0.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0132096 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
46.4 μM
MIC
PMID30744154;28556271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30744154/
RECORD: Rec_0140446 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
PN159
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PaperTranslocation of cell-penetrating peptides across the plasma membrane is controlled by cholesterol and microenvironment created by membranous proteins PMID25016968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25016968/
RECORD: Rec_0141704 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
Human erythrocytes
260 μM
EC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/8823199/ PMID8823199 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8823199/
RECORD: Rec_0147546 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
KLAL amphipathic peptide
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV Anti-HSV Entry inhibitor
And adenoviruses.The peptide shows antiviral activity against HSV by blocking virus entry
11 μM
IC50
PaperPharmacologically active antiviral peptides and methods of their use Evidence URLhttps://patents.google.com/patent/US20050130884/en PatentUS 20050130884
RECORD: Rec_0150430 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
Human erythrocytes
210 μM
EC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/8823199/ PMID8823199 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8823199/
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