Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC210H323N61O76S5

DescriptionStandard

        MEKVLDLDVQVKGNNNTNDSAGDERVTSHFLCSYGCGNTGSFNSFCC
    

Molecular Weight5078.50 Da

Isoelectric Point (pI)4.52

Net Charge (pH 7.0)-3.44

Net Charge (pH 7.4) -3.78

Charge Density (pH 7.0) -0.0733

GRAVY Index-0.43

Hydrophobic Moment 0.42

Boman Index-0.03

Instability Index-9.99

Aliphatic Index 51.70

Aromaticity 0.0851

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2252.04

LogP -32.48

H-bond Donors 80.0

H-bond Acceptors 79.0

Rotatable Bonds 169.0

Heavy Atoms 352.0

Ring Count 5.0

Amide Bonds 53.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0013447 VERIFIED: NO

Provenance & Taxonomy

OrganismStaphylococcus schweitzeri [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence