Peptide Database

Peptide NameSLAY-screened peptide P3472

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC112H166N34O25S2

DescriptionStandard

        TVFYPPCHFDRCLARRPFAR
    

Molecular Weight2452.86 Da

Isoelectric Point (pI)9.68

Net Charge (pH 7.0)2.47

Net Charge (pH 7.4) 2.19

Charge Density (pH 7.0) 0.1233

GRAVY Index-0.33

Hydrophobic Moment 0.59

Boman Index-0.17

Instability Index108.88

Aliphatic Index 44.00

Aromaticity 0.2000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 943.89

LogP -6.72

H-bond Donors 36.0

H-bond Acceptors 31.0

Rotatable Bonds 70.0

Heavy Atoms 173.0

Ring Count 8.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0344431 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/