Peptide Database

Peptide NameInsulin Glargine

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic

Standard StatusStandard

Sequence Length53 amino acids

Chemical FormulaC267H408N72O77S6

DescriptionStandard

        GIVEQCCTSICSLYQLENYCGFVNQHLCGSHLVEALYLVCGERGFFYTPKTRR
    

Molecular Weight6050.92 Da

Isoelectric Point (pI)6.88

Net Charge (pH 7.0)-0.12

Net Charge (pH 7.4) -0.52

Charge Density (pH 7.0) -0.0022

GRAVY Index0.10

Hydrophobic Moment 0.43

Boman Index0.10

Instability Index25.88

Aliphatic Index 82.64

Aromaticity 0.1321

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2403.76

LogP -22.64

H-bond Donors 90.0

H-bond Acceptors 85.0

Rotatable Bonds 195.0

Heavy Atoms 422.0

Ring Count 10.0

Amide Bonds 57.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0218877 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Escherichia coli [Bacterium]

FamilyInsulin

Tax ID9606;562

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideA6-A11, A7-B7, A20-B19

Other ModsAsnA21→Gly substitution; Arg added at B31 and B32

Bio-Activity Profile

Function

Antidiabetic Hypoglycemic Insulin analog

Half-LifeNot reported in humans; 30 h in mammalian reticulocytes.

PaperPubMed-linked source references: PMID:18454569; PMID:16805721; PMID:16049868; PMID:15525480; PMID:12904090; PMID:12860485; PMID:12324987; PMID:20424816; PMID:18034591 PMID18454569;16805721;16049868;15525480;12904090;12860485;12324987;20424816;18034591 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18454569/ PatentUS7476652