Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length355 amino acids

Chemical FormulaC1811H2869N469O508S8

DescriptionStandard

        MEYLVTAVGVVLFASQIVQQDHQAAPLHSRDQGGFTLSISELFIAIVFKVSRDSTGHLSVLLHNCQLSIGSVKIKLNEGSSWIYSFLSGYLEKAIHSKLDENICLNIKYRIQMMDAQLRKQKVLSQIDAFAQIDYSLVSSPAVFKSHINLDLKGTVYPVGNHTDPPFVPAPFGLPNKGDSMLHLGVSSYLLNSATLAYYRAGVFNIAITKDPSFLSSYNDLIYFICLQLTTTFNLTTAILKDFVPETASTRANLRVIKQKLIISLLLKRLQISLLRSAVGFSRVTLVENFLAYTLRTVVIPVINDKLGKGFLLPSLAHTTLVRPVIKMYQGHLVIFTDVHYKHEQGEDEDLHSQP
    

Molecular Weight39596.51 Da

Isoelectric Point (pI)8.93

Net Charge (pH 7.0)5.62

Net Charge (pH 7.4) 4.62

Charge Density (pH 7.0) 0.0158

GRAVY Index0.19

Hydrophobic Moment 0.65

Boman Index0.15

Instability Index39.72

Aliphatic Index 113.10

Aromaticity 0.0930

Extinction Coeff. Reduced 26360.00

Extinction Coeff. Oxidized 26485.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0379859 VERIFIED: NO

Provenance & Taxonomy

OrganismColinus virginianus [Animal]

FamilyBPI

Tax ID9014

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence