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MYP_092564
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Basic Information
[E]4[W]9-VmCT1-NH2 VmCT1 petide derivative
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C82H113N17O18
Standard
Sequence
FLGELWNVWKSVF
Physicochemical Analysis
1624.88 Da
6.00
-0.24
-0.44
-0.0183
0.59
0.49
0.43
31.14
104.62
0.3077
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
570.74
0.05
20.0
18.0
49.0
117.0
6.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0272039 VERIFIED: YES
Provenance & Taxonomy
Vaejovis mexicanus smithi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
hRBC
1.6
MHC
PMID27912176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27912176/
RECORD: Rec_0280507 VERIFIED: YES
Provenance & Taxonomy
Vaejovis mexicanus smithi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
3.12
MIC
PMID27912176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27912176/
RECORD: Rec_0281950 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus (ATCC 29213)
12.5 μM
MIC
PaperNovel designed VmCT1 analogs with increased antimicrobial activity. Eur J Med Chem. 2017 Jan 27;126:456-463. doi: 10.1016/j.ejmech.2016.11.040. PMID: 27912176. PMID27912176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27912176/
RECORD: Rec_0297714 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic
human red blood cells
PaperNovel designed VmCT1 analogs with increased antimicrobial activity. Eur J Med Chem. 2017 Jan 27;126:456-463. doi: 10.1016/j.ejmech.2016.11.040. PMID: 27912176. PMID27912176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27912176/
RECORD: Rec_0335389 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic
PaperNovel designed VmCT1 analogs with increased antimicrobial activity. Eur J Med Chem. 2017 Jan 27;126:456-463. doi: 10.1016/j.ejmech.2016.11.040. PMID: 27912176. PMID27912176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27912176/
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