Peptide Database

Peptide NameOstricacin-1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC182H267N51O41S6

DescriptionStandard

        LFCRKGTCHFGGCPAHLVKVGSCFGFRACCKWPWDV
    

Molecular Weight4017.77 Da

Isoelectric Point (pI)8.94

Net Charge (pH 7.0)3.87

Net Charge (pH 7.4) 3.48

Charge Density (pH 7.0) 0.1076

GRAVY Index0.30

Hydrophobic Moment 0.54

Boman Index0.16

Instability Index37.89

Aliphatic Index 51.39

Aromaticity 0.1667

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1432.80

LogP -10.67

H-bond Donors 57.0

H-bond Acceptors 53.0

Rotatable Bonds 122.0

Heavy Atoms 280.0

Ring Count 12.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0180515 VERIFIED: YES

Provenance & Taxonomy

OrganismStruthio camelus [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide3-29; 8-23; 13-30

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetStaphylococcus aureus

Activity1.25-6.7 μg/mL

MethodMIC

RECORD: Rec_0215263 VERIFIED: YES

Provenance & Taxonomy

OrganismStruthio camelus [Animal]

FamilyBeta-defensin; Defensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-MRSA Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli

RECORD: Rec_0217789 VERIFIED: YES

Provenance & Taxonomy

OrganismStruthio camelus [Animal]

FamilyBeta-defensin; Defensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-MRSA Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0312901 VERIFIED: YES

Provenance & Taxonomy

OrganismStruthio camelus [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli O157:H7

Activity0.96 μg/mL

MethodMIC

RECORD: Rec_0330308 VERIFIED: YES

Provenance & Taxonomy

OrganismStruthio camelus [Animal]

Structure & Mods

ConfigDNA-encoded linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)

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