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MYP_092556
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Basic Information
Defensin-derived D-Peptide B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
9 amino acids
C50H98N24O10
Standard
Sequence
RLRLRIGRR
Physicochemical Analysis
1195.47 Da
12.00
4.76
4.56
0.5289
-1.20
0.68
-0.96
115.33
130.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
605.62
-5.64
25.0
15.0
43.0
84.0
0.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0178177 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Anticancer Cytotoxic
Human cervical carcinoma HeLa
188
IC50
PMID19584534;15003352;19154767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19584534/
RECORD: Rec_0233575 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Escherichia coli JM109
20 μg/mL
MIC
PMID19584534;15003352;19154767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19584534/
RECORD: Rec_0236747 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Staphylococcus aureus KO-4
30 μg/mL
MIC
PMID19584534;15003352;19154767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19584534/
RECORD: Rec_0264838 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Anticancer Cytotoxic
Human lung cancer VA-13
640 μM
IC50
PMID19584534;15003352;19154767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19584534/
RECORD: Rec_0290152 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
L-type peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antitrypanosomal Antiparasitic
Trypanosoma brucei brucei ILTat 1.1 (blood stage form)
40 μM
Microscopy (Neubauer hemocytometer)
PaperAntiparasitic peptides PMID23615879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23615879/
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