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MYP_092520
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
15 amino acids
C88H132N22O25S
Standard
Sequence
FRKQNPDIVIYQYMD
Physicochemical Analysis
1930.19 Da
6.13
-0.24
-0.45
-0.0158
-0.81
0.23
-0.13
36.75
71.33
0.2000
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
794.18
-4.92
26.0
26.0
62.0
136.0
4.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0100277 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 46.7%, C 53.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0124784 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by integrase
97 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase. | Oz Gleenberg I, Avidan O, Goldgur Y, Herschhorn A, Hizi A. | J Biol Chem. 2005 Jun 10;280(23):21987-96. | DOI:10.1074/jbc.M414679200 | PMID:15790559 PMID15790559 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/
RECORD: Rec_0209852 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
119 μM
IC50
PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase. PMID15790559 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/
RECORD: Rec_0295739 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of disintegration catalyzed by integrase
270 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase. | Oz Gleenberg I, Avidan O, Goldgur Y, Herschhorn A, Hizi A. | J Biol Chem. 2005 Jun 10;280(23):21987-96. | DOI:10.1074/jbc.M414679200 | PMID:15790559 PMID15790559 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/
RECORD: Rec_0301569 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of disintegration catalyzed by integrase
270 μM
IC50
PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase PMID15790559 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/
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