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MYP_092415
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Basic Information
RN7-IN9(designed based on indolicidin and ranalexin)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C109H152N28O17
Standard
Sequence
FLGGLIKKWPWWPWRR
Physicochemical Analysis
2126.55 Da
12.00
3.76
3.55
0.2349
-0.59
0.50
0.07
43.98
73.12
0.3125
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
721.24
2.01
27.0
21.0
61.0
154.0
11.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0209094 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
7.81 μg/mL
MIC
PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0238311 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
7.81 μg/mL
MIC
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0291184 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S. pneumoniae
7.81-15.62 μg/mL
MIC
PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0306399 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus pneumoniae(30 clinical isolates)
7.81-15.62 μg/mL
MIC
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0309298 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Methicillin resistant Staphylococcus aureus (MRSA)
7.81 μg/mL
MIC
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
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