Peptide Database

Peptide NameProkineticin Bm8-d

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length77 amino acids

Chemical FormulaC326H528N104O110S10

DescriptionStandard

        AVITGVCDRDAQCGSGTCCAASAFSRNIRFCVPLGNNGEECHPASHKVPYNGKRLSSLCPCNTGLTCSKSGEKSQCS
    

Molecular Weight7984.96 Da

Isoelectric Point (pI)8.40

Net Charge (pH 7.0)2.88

Net Charge (pH 7.4) 2.43

Charge Density (pH 7.0) 0.0374

GRAVY Index-0.28

Hydrophobic Moment 0.62

Boman Index-0.05

Instability Index39.82

Aliphatic Index 53.25

Aromaticity 0.0390

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 2115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3440.38

LogP -52.53

H-bond Donors 129.0

H-bond Acceptors 125.0

Rotatable Bonds 260.0

Heavy Atoms 550.0

Ring Count 9.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0258896 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyProkineticin Bm8

Tax ID161274

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0270096 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyProkineticin Bm8

Tax ID161274

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

TargetDRG neurons

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0421068 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyProkineticin Bm8

Tax ID161274

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

Targetguinea-pig gastrointestinal (GI) smooth muscle

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour