Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length481 amino acids

Chemical FormulaC2353H3673N597O688S27

DescriptionStandard

        MLPCVIVVFVLLSCACGENPAVQVILTNKGLQYGKHEGTGWIQEKLEKITFPDISGSVNIHIGRVYYTLSGVTIKKCDLPEPSVEFVQQSGLTTSIAGLSFALAGEWRNHFGLIHDSGSFDMAIFNIDVTSAVKLGSNAGGHLSVTSVNCTASVGDVSMQFHGGASWIFQPFVKYFKGHIIGIIQSKICPEVEDTIMNLDHHLQAMNVSFDVNEVLSFDVPLTGDPDIEPSNMKLGFKGEFHSIETHAEPPFVAQEFVLPELAGYMLSVGLSEFTLNSASFGYFSAGQLQAFINDSMIPPYIPFRLNTSAMGGFIPQLPKMYPGLLMNLQVNARDAPMFSFQPGSGVLDVHICVKASATESNGTQVPLFTLYIDSRFTGKMMIADGKLKGSMMLNNVTLTLGSSEIGDFKTDALENGIKSGMVVVLGKLNAKLGEGIMLPRMKHAQLVNTVLKMQKGFVGIYSDVQILQTDRSSYLSTSYL
    

Molecular Weight52198.67 Da

Isoelectric Point (pI)5.61

Net Charge (pH 7.0)-10.39

Net Charge (pH 7.4) -11.47

Charge Density (pH 7.0) -0.0216

GRAVY Index0.18

Hydrophobic Moment 0.62

Boman Index0.20

Instability Index35.10

Aliphatic Index 93.78

Aromaticity 0.0915

Extinction Coeff. Reduced 34380.00

Extinction Coeff. Oxidized 34755.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0344822 VERIFIED: NO

Provenance & Taxonomy

OrganismPoecilia latipinna [Bacterium]

FamilyBPI

Tax ID48699

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence