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MYP_092395
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Basic Information
FIV Egp (734-768)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
35 amino acids
C191H297N51O60S
Standard
Sequence
EWYNQTKDLQQKFYEIIMDIEQNNVQGKKGIQQLQ
Physicochemical Analysis
4299.77 Da
4.94
-1.16
-1.34
-0.0332
-1.20
0.59
-0.18
56.34
75.14
0.1143
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1893.77
-17.12
60.0
60.0
153.0
303.0
5.0
45.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0039079 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
>2.304 μM
IC90
PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0046105 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Human cervical carcinoma HeLa
0-10 % Cytotoxicity
Cytotoxicity
PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0073448 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | CEM4/IIIb cells; MOLT4 cells
2.304 μM
EC90
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperC-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. | Medinas RJ, Lambert DM, Tompkins WA. | J Virol. 2002 Sep;76(18):9079-86. | DOI:10.1128/jvi.76.18.9079-9086.2002 | PMID:12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0094717 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Feline immunodeficiency virus (FIV)
PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0118062 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-FIV Fusion inhibition
Feline immunodeficiency virus (FIV) | FIV/CrFK cells; HeLa cells
0.012 μM
EC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperC-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. | Medinas RJ, Lambert DM, Tompkins WA. | J Virol. 2002 Sep;76(18):9079-86. | DOI:10.1128/jvi.76.18.9079-9086.2002 | PMID:12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
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