Peptide Database

Peptide NameSLAY-screened peptide P5009

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC116H169N29O36S

DescriptionStandard

        YDDCDDITDRREKFYLIFIH
    

Molecular Weight2577.82 Da

Isoelectric Point (pI)4.45

Net Charge (pH 7.0)-3.16

Net Charge (pH 7.4) -3.43

Charge Density (pH 7.0) -0.1579

GRAVY Index-0.75

Hydrophobic Moment 0.30

Boman Index-0.19

Instability Index78.31

Aliphatic Index 78.00

Aromaticity 0.2000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1079.21

LogP -6.65

H-bond Donors 39.0

H-bond Acceptors 35.0

Rotatable Bonds 84.0

Heavy Atoms 182.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0341437 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/