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MYP_092323
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Basic Information
Brevinin-2Ea (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
33 amino acids
C138H243N41O44S2
Standard
Sequence
GILDTLKNLAISAAKGAAQGLVNKASCKLSGQC
Physicochemical Analysis
3244.78 Da
9.31
2.74
2.50
0.0830
0.31
0.42
0.14
12.88
109.70
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1389.18
-17.97
49.0
49.0
114.0
225.0
0.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0344910 VERIFIED: YES
Provenance & Taxonomy
Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial
PaperM.F. Ali et al. / Peptides 24 (2003) 955-961. Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex Evidence URLhttps://www.uniprot.org/uniprotkb/P40837/entry
RECORD: Rec_0388211 VERIFIED: YES
Provenance & Taxonomy
Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
PaperAntimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
RECORD: Rec_0389566 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperSimmaco M., Mignogna G., Barra D., Bossa F.;. "Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides."; J. Biol. Chem. 269:11956-11961. Evidence URLhttps://www.uniprot.org/uniprotkb/BR2A_RANES/entry
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