Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length453 amino acids

Chemical FormulaC2229H3569N561O646S21

DescriptionStandard

        MSPCCCLALLALLPFALATNPGVKVKLTEKGIEYGKQIGMASLQQKLKTMKVPDLSGTERVAPIGKVKYSLTGITIVNLGLPYSALALVPDTGIRLSITNAFISLHGNWKIRYLSFIKDSGSFDLEVNGLTVTDSITIKSDETGRPTVSSVNCVANVGSASIKFHGGASWLYNLFSAYIDKALRSALQKQICPLVADTITDMNPHLKTLNVLAKVDKYAEVEYSMVTSPTISNTSIDFSLKGEFYNIGKHQEPPFSPTPFSLPPQVNNMLYIGMSAFTTNSAGFVYNNAGALSLYITDDMIAKRFPSMMMKLLVKTVKEPTIFFEPNNVTVQASGSVTAYAIQPNTTLSPLFVLNMEGSVSARLYVTGVKLAGAVTLNKIEMTLETSYVGQFQVRSLDNIFLMVLKVAVIPKVNARLEKGFPLPSIGKMNLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight49235.92 Da

Isoelectric Point (pI)9.10

Net Charge (pH 7.0)8.81

Net Charge (pH 7.4) 8.21

Charge Density (pH 7.0) 0.0195

GRAVY Index0.20

Hydrophobic Moment 0.70

Boman Index0.17

Instability Index27.36

Aliphatic Index 100.68

Aromaticity 0.0839

Extinction Coeff. Reduced 34840.00

Extinction Coeff. Oxidized 35090.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0116984 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus tshawytscha [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence