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MYP_092170
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Basic Information
Aβ(1– 40)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Standard
40 amino acids
C194H295N53O58S
Standard
Sequence
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Physicochemical Analysis
4329.80 Da
5.31
-2.97
-3.34
-0.0742
0.06
0.39
0.17
18.58
90.00
0.1000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1768.87
-15.73
60.0
59.0
144.0
306.0
7.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015977 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Amyloid-beta
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Neuroprotective
Radioactivity measured by scintillation counter
Intravenouly injected into male B6SJLF1/J mice and blood samples collected from tail vein to prepare plasma samples, in vivo; 144 s
PMID15322125 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15322125/
RECORD: Rec_0049554 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis ATCC 12228
50 μg/mL
MIC
PMID20209079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20209079/
RECORD: Rec_0053480 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0102882 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
influenza A virus (White et al. 2014 ). Synergy:AMPs: It appears to show synergistic effects
PaperThe Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide
RECORD: Rec_0111396 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
S. salivarius
50 μg/mL
MIC
PMID20209079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20209079/
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