Peptide Database

Peptide NameIBP02V4

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC173H294N48O61

DescriptionStandard

        ELSGINASVVNLQKEIDRLNEVAKNLNESLIDLQEL
    

Molecular Weight4022.47 Da

Isoelectric Point (pI)4.25

Net Charge (pH 7.0)-4.15

Net Charge (pH 7.4) -4.33

Charge Density (pH 7.0) -0.1153

GRAVY Index-0.22

Hydrophobic Moment 0.69

Boman Index-0.02

Instability Index39.43

Aliphatic Index 138.06

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1819.18

LogP -18.85

H-bond Donors 59.0

H-bond Acceptors 57.0

Rotatable Bonds 144.0

Heavy Atoms 282.0

Ring Count 0.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0171151 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermPEG8-K(Chol)

Other ModsPEG8-K(Chol)

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Fusion inhibition

TargetSARS-CoV-2 pseudovirus; Huh-7 cells

Activity0.0152 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 30 min; E. coli: >10 h

PaperSARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. | Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y. | Signal Transduct Target Ther. 2021 Aug 3;6(1):294. | DOI:10.1038/s41392-021-00698-x | PMID:34344868 PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/

RECORD: Rec_0180517 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermPEG8-K(Chol)

Other ModsPEG8-K(Chol)

Bio-Activity Profile

Function

Antiviral Anti-HCoV-NL63 Fusion inhibition

TargetHCoV-NL63; Huh-7 cells

Activity0.0663±0.0031 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 30 min; E. coli: >10 h

PaperSARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. | Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y. | Signal Transduct Target Ther. 2021 Aug 3;6(1):294. | DOI:10.1038/s41392-021-00698-x | PMID:34344868 PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/

RECORD: Rec_0182856 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermPEG8-K(Chol)

Other ModsC-terminal PEG8-K(Chol)

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2 Cytotoxic

RECORD: Rec_0208674 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermPEG8-K(Chol)

Other ModsC-terminal PEG8-K(Chol)

Bio-Activity Profile

Function

Antiviral Antimicrobial Anti-SARS-CoV-2

TargetHCoV-NL63 pseudovirus; Huh-7 cells

Activity0.0663±0.0031 μM

MethodIC50

RECORD: Rec_0230549 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermPEG8-K(Chol)

Other ModsPEG8-K(Chol)

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Fusion inhibition

TargetSARS-CoV-2 spike protein

Activity0.0003±0.00002 μM

MethodIC50 (cell-cell fusion inhibition)

Half-LifeMammalian: 1 h; Yeast: 30 min; E. coli: >10 h

PaperSARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. | Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y. | Signal Transduct Target Ther. 2021 Aug 3;6(1):294. | DOI:10.1038/s41392-021-00698-x | PMID:34344868 PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/

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