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MYP_092021
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Basic Information
Rex (1-21) -RTD
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
32 amino acids
C180H314N78O39S
Standard
Sequence
MPKTRRRPRRSQRKRPPTPWPYGRKKRRQRRR
Physicochemical Analysis
4226.98 Da
12.00
16.50
16.27
0.5155
-2.92
0.68
-1.19
189.11
0.00
0.0625
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2004.35
-23.26
77.0
57.0
141.0
298.0
9.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024586 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | PM1-CCR5 cells
2.5±0.76 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4. | Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M. | Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8. | DOI:10.1016/j.biocel.2010.05.005 | PMID:20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0028848 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 Bal | PM1-CCR5 cells
10 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4. | Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M. | Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8. | DOI:10.1016/j.biocel.2010.05.005 | PMID:20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0053078 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 IIIB
PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0144566 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 IIIB:inhibition of virus replication in PM1-CCR5 cells
2.5±0.76 μM
EC50
PaperPubMed PMID: 20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0386771 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
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