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MYP_091757
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Basic Information
Syn-safencin-92
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
25 amino acids
C153H250N44O30
Standard
Sequence
AWKKTIRQYLKNKIKKKWRKAVIAW
Physicochemical Analysis
3185.90 Da
11.36
9.79
9.59
0.3915
-1.00
0.71
-0.32
13.57
86.00
0.1600
17990.00
17990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1267.69
-4.87
47.0
40.0
112.0
227.0
7.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010607 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiparasitic Toxicity
THP-1 cells
<20 μM
CC50
PaperRationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties PMID36342284 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36342284/
RECORD: Rec_0070694 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiparasitic
L. donovani
0.90 μM
IC50
PaperRationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties PMID36342284 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36342284/
RECORD: Rec_0077564 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
Human keratinocytes HaCat
10 μM
Cytotoxicity
PMID29463889 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29463889/
RECORD: Rec_0164335 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Xanthomonas axonopodis pv. phaseoli ATCC 9563
1 μM
MIC
PMID29463889 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29463889/
RECORD: Rec_0164700 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli BL21
4 μM
MIC
PMID29463889 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29463889/
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