Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length476 amino acids

Chemical FormulaC2410H3708N590O712S20

DescriptionStandard

        MWLVTTFLLMAVTQTHADYSSLQAVLSQKGLQKVSHWMTDWLQNEMSKITLPDVSGSVDIFLGLVHYVLHDMHVVRCDLPEPSVAFSEGTGVSLQVNGLSLAINGLWNTQFGIIHDSGWFDLAIYTINFNTLLEFQSTEEHLSISSVMCSADVGSVQVHFHGGASFFFQPFVEKFSGRIKNMIQERICPGFQEGIENIDKDLAASDNIKMDPYVYLNVSLTDSPAVFDNGFELYIKGEFYSLSSPSEPPFSPNHFELPWKADYMLSVGMSEFCVNSAAFAYLNSGVLNITITDDMIPKSSPIHLNTSQFGSLIPQLPKLYPDMEMEVVLYASDTPLISLNQTVINVNLSASAKFYAVKTNTDLVPLFRLDMQYSFNAKVRIDDQLLKGVLELNNLTIVLGSTEIDKFDTTPFQTMVKLALNSFVLPKLNAQLKEGLPLPRVKGFSLTNSVMTIENGFLVVATDISSPFDFLQSDKL
    

Molecular Weight52980.05 Da

Isoelectric Point (pI)4.72

Net Charge (pH 7.0)-22.52

Net Charge (pH 7.4) -23.46

Charge Density (pH 7.0) -0.0473

GRAVY Index0.13

Hydrophobic Moment 0.65

Boman Index0.18

Instability Index40.23

Aliphatic Index 97.42

Aromaticity 0.1071

Extinction Coeff. Reduced 52370.00

Extinction Coeff. Oxidized 52620.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0080466 VERIFIED: NO

Provenance & Taxonomy

OrganismPangasianodon hypophthalmus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence