Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2208H3494N576O610S16

DescriptionStandard

        MARGADNTLRWATLVALAALGTAVTAAANPGIVARITQKGLDYACQQGVATLRKELEKITIPTFSGSFKIKYFGKGRYNFYSKASGNFDLSVEGISVLASLRLGYDPTSGHSTVSCSSCRSHINRVHVRTSGSSLKWLIQLFHRNIESALRKAMESKICKMLTNTVSSKLQPYFQTLPVTAKVDRMVGINYSLVAPPKATAENLDGLLKGEFFSLDHPSPPPFAPPALALPADHDRMVYLCISEYFFNTAGLVYQKAGVLNLTISNSMIPKKSLFSLTTNFFGTLIPKVSTMFPNMEMQFLIWASFPPHLTVHPSGLDLTFVLETQAFAVLPNASLAPLFLIEMNSSISVDIGVRSKRLIGELRLNKLLLELKHSNIGPFSVELLQAVMNFAVPTLVLPKINEKLQRGFPLPLPAYIQLSNLVLQPHQDFLLFGADVRYS
    

Molecular Weight48381.89 Da

Isoelectric Point (pI)9.53

Net Charge (pH 7.0)14.34

Net Charge (pH 7.4) 13.46

Charge Density (pH 7.0) 0.0326

GRAVY Index0.16

Hydrophobic Moment 0.81

Boman Index0.15

Instability Index34.74

Aliphatic Index 100.86

Aromaticity 0.0932

Extinction Coeff. Reduced 34380.00

Extinction Coeff. Oxidized 34630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0102209 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyBPI/LBP

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence