Peptide Database

Peptide NameSLAY-screened peptide P124

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC86H142N24O27

DescriptionStandard

        VPLAVASEPGPTLNGPPRAT
    

Molecular Weight1944.19 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-0.26

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) -0.0132

GRAVY Index-0.06

Hydrophobic Moment 0.36

Boman Index0.17

Instability Index36.73

Aliphatic Index 83.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 775.25

LogP -9.38

H-bond Donors 24.0

H-bond Acceptors 27.0

Rotatable Bonds 52.0

Heavy Atoms 137.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296224 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/