Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length196 amino acids

Chemical FormulaC982H1558N270O262S11

DescriptionStandard

        PKTPPMAHEPMLLLAVTEFVANSAAFTYFTAGALRRNISSDMLPQRFPLQLRTKSMEVFCPQLQERYPDQPMELHLWARRQPLLSCHPDALHGTLFGSAEAFVVLPNATRVPAFLLNIDANVTGKPTISRNRLGGTVRLTGLVPDPELAWTPLPALCRAQGLPVPQVKRLETLLKFGLWLFGIPRANSKCCSCPVP
    

Molecular Weight21691.24 Da

Isoelectric Point (pI)9.43

Net Charge (pH 7.0)7.27

Net Charge (pH 7.4) 6.89

Charge Density (pH 7.0) 0.0371

GRAVY Index0.02

Hydrophobic Moment 0.54

Boman Index0.09

Instability Index54.72

Aliphatic Index 92.60

Aromaticity 0.0765

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8332.03

LogP -100.76

H-bond Donors 288.0

H-bond Acceptors 284.0

Rotatable Bonds 680.0

Heavy Atoms 1525.0

Ring Count 45.0

Amide Bonds 210.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0055417 VERIFIED: NO

Provenance & Taxonomy

OrganismDrymodes brunneopygia [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria