Peptide Database

Peptide NameSLAY-screened peptide P4707

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC64H98N16O23S3

DescriptionStandard

        LPDTSFSTVCHCMD
    

Molecular Weight1555.75 Da

Isoelectric Point (pI)4.51

Net Charge (pH 7.0)-2.17

Net Charge (pH 7.4) -2.45

Charge Density (pH 7.0) -0.1548

GRAVY Index0.21

Hydrophobic Moment 0.33

Boman Index0.14

Instability Index53.49

Aliphatic Index 48.57

Aromaticity 0.0714

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 617.03

LogP -7.57

H-bond Donors 23.0

H-bond Acceptors 25.0

Rotatable Bonds 46.0

Heavy Atoms 106.0

Ring Count 3.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0115008 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/