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MYP_091394
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Basic Information
Citropin 1.1 M14
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C81H141N19O20
Standard
Sequence
GLFDVIAKVASVIKKL
Physicochemical Analysis
1701.10 Da
9.70
1.76
1.55
0.1099
1.20
0.63
0.34
1.17
164.38
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
635.41
-2.41
22.0
22.0
59.0
120.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0294558 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Citropin / Aurein-like peptide family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0300261 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Amphibian skin secretions
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
Lung tumor cell line
5
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1 PMID12631273;9266696 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0325543 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis VanB
16 μg/mL
MIC
PMID20564028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564028/
RECORD: Rec_0332786 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
3 μM
MIC
PMID20564028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564028/
RECORD: Rec_0340337 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Amphibian skin secretions
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
Prostate tumor cell line
5
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1 PMID12631273;9266696 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
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