Peptide Database

Peptide NameSLAY-screened peptide P1193

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC75H109N19O21

DescriptionStandard

        GNYIWPILSDHIAN
    

Molecular Weight1612.78 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-1.15

Net Charge (pH 7.4) -1.41

Charge Density (pH 7.0) -0.0823

GRAVY Index0.03

Hydrophobic Moment 0.38

Boman Index0.32

Instability Index48.36

Aliphatic Index 118.57

Aromaticity 0.1429

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 641.24

LogP -4.10

H-bond Donors 21.0

H-bond Acceptors 21.0

Rotatable Bonds 47.0

Heavy Atoms 115.0

Ring Count 5.0

Amide Bonds 15.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0391315 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/