Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length442 amino acids

Chemical FormulaC2229H3518N598O620S8

DescriptionStandard

        TNPGFVVRITQAGLDYAHQQGIAVLEKELAQLKLPDISGDFRIRHVGKVRYEISRLDLRSFHLPYSRISLVPNVGLQVSISNAFAEVDGNWRVKIHFIRDHGSFDLKVENIYIKINLKLGSDASGKPTIDTSDCSTRISNVRVHFSGKFGWLYNLFHSAIESRFRKILESKVCENVVSSVRSELQPYLRTLPVTARIDAVAGIDYSLVAPPTTTAQSLDVDLKGEFFSLAHRSAVPFPPLALAFPPDHDRMVYFGVSSYFFNTAGFAYHGAGALVFEITDSLIPKGIDIHLNTSTFSAFIPQLEKMYPDMLMKLRLSASSAPFLNIGPGGLSLKPVVDIQAYAILPNSSLAPLFLLSLVSNVSAVIDVKSGHIVGSLKVGRMKLSLKHSDVGTFQVRTLQSIMNIFASSILLPRLNARLDQGFPLPLPDRIQLSNILVRFHQ
    

Molecular Weight48869.93 Da

Isoelectric Point (pI)9.41

Net Charge (pH 7.0)9.63

Net Charge (pH 7.4) 8.62

Charge Density (pH 7.0) 0.0218

GRAVY Index0.13

Hydrophobic Moment 0.67

Boman Index0.12

Instability Index34.58

Aliphatic Index 106.29

Aromaticity 0.0928

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29005.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0184736 VERIFIED: NO

Provenance & Taxonomy

OrganismPygoscelis adeliae [Animal]

FamilyBPI/LBP

Tax ID9238

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria