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MYP_091222
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Basic Information
Amurin-2b
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C111H178N22O23S2
Standard
Sequence
FLPLLLSALPSFLCLVFKKC
Physicochemical Analysis
2252.86 Da
8.90
1.74
1.50
0.0869
1.67
0.41
0.51
40.51
156.00
0.1500
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
691.14
0.45
25.0
27.0
70.0
158.0
5.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0153222 VERIFIED: YES
Provenance & Taxonomy
Rana zhenhaiensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa ATCC 9027
44 μM
MIC
PMID22943778 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22943778/
RECORD: Rec_0210219 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Antimicrobial Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0281651 VERIFIED: YES
Provenance & Taxonomy
Rana amurensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
512 μM
MIC
PMID29366784 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29366784/
RECORD: Rec_0298095 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Rana amurensis [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
14-20
Bio-Activity Profile
Antimicrobial
Note that Amurin-2 is the same as AP602 in sequence. Amurin-2a is inactive
>100 μM
MIC
PaperIdentification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues
RECORD: Rec_0309368 VERIFIED: YES
Provenance & Taxonomy
Rana zhenhaiensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human RBC
5 μM
HC50
PMID22943778 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22943778/
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