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MYP_091222
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Basic Information
Amurin-2b
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C111H178N22O23S2
Standard
Sequence
FLPLLLSALPSFLCLVFKKC
Physicochemical Analysis
2252.86 Da
8.90
1.74
1.50
0.0869
1.67
0.41
0.51
40.51
156.00
0.1500
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
691.14
0.45
25.0
27.0
70.0
158.0
5.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0039100 VERIFIED: YES
Provenance & Taxonomy
Rana amurensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
MRSA
512 μM
MIC
PMID29366784 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29366784/
RECORD: Rec_0079362 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Rana amurensis [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
14-20
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
32 μM
MIC
PaperIdentification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues
RECORD: Rec_0144607 VERIFIED: YES
Provenance & Taxonomy
Rana amurensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
512 μM
MIC
PMID29366784 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29366784/
RECORD: Rec_0146283 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
5 μM
HC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/22943778/ PMID22943778 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22943778/
RECORD: Rec_0147057 VERIFIED: YES
Provenance & Taxonomy
Rana zhenhaiensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli ATCC 25922
33 μM
MIC
PMID22943778 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22943778/
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