MYP_091188
RKK
Antimicrobial
Antimicrobial
▸
Antibacterial
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Standard
7 amino acids
C40H67N13O8S
Standard
RAWKMAK
890.11 Da
11.17
2.76
2.55
0.3940
-1.10
0.72
-0.41
72.77
28.57
0.1429
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
367.65
-1.65
14.0
12.0
30.0
62.0
2.0
6.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0270789
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The J (position: 5) in sequence is norleucine. The Ⓧ (position: 2 and 6) indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
human red blood cells
25 μM
Hemolysis
RECORD: Rec_0373414
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The J (position: 5) in sequence is norleucine. The Ⓧ (position: 2 and 6) indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Escherichia coli ATCC 25922
12.5 μM
MIC
RECORD: Rec_0384406
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The J (position: 5) in sequence is norleucine. The Ⓧ (position: 2 and 6) indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Salmonella typhimurium ATCC 14028
25 μM
MIC
RECORD: Rec_0395807
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The J (position: 5) in sequence is norleucine. The Ⓧ (position: 2 and 6) indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Staphylococcus epidermidis ATCC 12228
12.5 μM
MIC
RECORD: Rec_0413370
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The J (position: 5) in sequence is norleucine. The Ⓧ (position: 2 and 6) indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Bacillus subtilis ATCC 6633
6.3 μM
MIC
Showing 5 records on this page · Page 2 of 2