Peptide Database

Peptide NameEndothelin-2

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC115H164N26O32S4

DescriptionStandard

        CSCSSWLDKECVYFCHLDIIW
    

Molecular Weight2550.95 Da

Isoelectric Point (pI)4.54

Net Charge (pH 7.0)-2.19

Net Charge (pH 7.4) -2.51

Charge Density (pH 7.0) -0.1043

GRAVY Index0.50

Hydrophobic Moment 0.30

Boman Index0.25

Instability Index65.32

Aliphatic Index 88.10

Aromaticity 0.1905

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 924.42

LogP -4.82

H-bond Donors 37.0

H-bond Acceptors 35.0

Rotatable Bonds 78.0

Heavy Atoms 177.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0405463 VERIFIED: NO

Provenance & Taxonomy

OrganismEquus caballus [Animal]

FamilyEndothelin/sarafotoxin

Tax ID9796

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide1-15; 3-11

Bio-Activity Profile

Function

Vasoactive Hormone

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