Peptide Database

Peptide NameGrowth hormone-releasing factor

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length45 amino acids

Chemical FormulaC217H353N63O77

DescriptionStandard

        HADGLLDRALRDILVQLSARKYLHSLTAVRVGEEEEDEEDSEPLS
    

Molecular Weight5076.50 Da

Isoelectric Point (pI)4.45

Net Charge (pH 7.0)-7.04

Net Charge (pH 7.4) -7.36

Charge Density (pH 7.0) -0.1565

GRAVY Index-0.59

Hydrophobic Moment 0.73

Boman Index-0.15

Instability Index61.59

Aliphatic Index 106.22

Aromaticity 0.0222

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2277.98

LogP -22.93

H-bond Donors 79.0

H-bond Acceptors 72.0

Rotatable Bonds 174.0

Heavy Atoms 357.0

Ring Count 4.0

Amide Bonds 45.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0033634 VERIFIED: YES

Provenance & Taxonomy

OrganismClarias macrocephalus [Animal]

FamilyGrowth hormone-releasing factor

Tax ID35657

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0255830 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0371008 VERIFIED: NO

Provenance & Taxonomy

OrganismClarias macrocephalus [Animal]

FamilyGlucagon

Tax ID35657

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic