Peptide Database

Peptide NameBTD-7 (theta-defensin; primates, mammals, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC84H141N33O20S6

DescriptionStandard

        RCVCTRGFCRCFCRRGVC
    

Molecular Weight2125.62 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)4.70

Net Charge (pH 7.4) 4.41

Charge Density (pH 7.0) 0.2611

GRAVY Index0.28

Hydrophobic Moment 0.77

Boman Index-0.30

Instability Index45.76

Aliphatic Index 32.22

Aromaticity 0.1111

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 887.75

LogP -11.02

H-bond Donors 41.0

H-bond Acceptors 31.0

Rotatable Bonds 68.0

Heavy Atoms 143.0

Ring Count 2.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0386045 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)

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