Peptide Database

Peptide NameLantibiotic macedocin (Lantibiotic streptococcin A-FF22)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length84 amino acids

Chemical FormulaC440H690N106O123S3

DescriptionStandard

        MQNKYEAVDSIKEISLEELDQIIGAGKNGVFKTISHEYRMNSFQFYSLVVLNVMSLVILDVATKRGKPLFVFSFKGGTFLLLSY
    

Molecular Weight9529.02 Da

Isoelectric Point (pI)7.99

Net Charge (pH 7.0)0.59

Net Charge (pH 7.4) 0.30

Charge Density (pH 7.0) 0.0071

GRAVY Index0.23

Hydrophobic Moment 0.57

Boman Index0.17

Instability Index19.55

Aliphatic Index 105.48

Aromaticity 0.1310

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3707.93

LogP -27.75

H-bond Donors 128.0

H-bond Acceptors 128.0

Rotatable Bonds 324.0

Heavy Atoms 672.0

Ring Count 13.0

Amide Bonds 90.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0172035 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus vestibularis [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Non-hemolytic

MethodQualitative functional evidence