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MYP_091100
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Basic Information
DENV-2 gp (412-444), DN59
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition ▸ Release inhibitor
Antiviral ▸ Virucidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
33 amino acids
C161H240N38O44S
Standard
Sequence
MAILGDTAWDFGSLGGVFTSIGKALHQVFGAIY
Physicochemical Analysis
3443.92 Da
5.19
-1.41
-1.68
-0.0428
0.78
0.61
0.46
8.74
100.61
0.1515
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1283.85
-9.42
45.0
45.0
109.0
244.0
7.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0327454 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Central European encephalitis virus (CEEV)
PMID23226444 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226444/
RECORD: Rec_0340056 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 57.6%, E 0.0%, T 15.2%, C 27.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0386659 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-3
PMID23226444 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226444/
RECORD: Rec_0401066 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Dengue virus(DENV):inhibition of DENV infection in LLCKM-2 monkey kidney epithelial cells
IC50
PMID31351847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31351847/
RECORD: Rec_0418321 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-WNV Fusion inhibition
West Nile virus (WNV) | epithelial cells
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses. | da Silva-Júnior EF, de Araújo-Júnior JX. | Bioorg Med Chem. 2019 Sep 15;27(18):3963-3978. | DOI:10.1016/j.bmc.2019.07.038 | PMID:31351847 PMID31351847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31351847/
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