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MYP_091100
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Basic Information
DENV-2 gp (412-444), DN59
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition ▸ Release inhibitor
Antiviral ▸ Virucidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
33 amino acids
C161H240N38O44S
Standard
Sequence
MAILGDTAWDFGSLGGVFTSIGKALHQVFGAIY
Physicochemical Analysis
3443.92 Da
5.19
-1.41
-1.68
-0.0428
0.78
0.61
0.46
8.74
100.61
0.1515
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1283.85
-9.42
45.0
45.0
109.0
244.0
7.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0217434 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 2 virus (Antibody dependent enhancement effect); K562
6 μM
ADE inhibition assay
PaperViral entry inhibitors block dengue antibody-dependent enhancement in vitro. | Nicholson CO, Costin JM, Rowe DK, Lin L, Jenwitheesuk E, Samudrala R, Isern S, Michael SF. | Antiviral Res. 2011 | PMID:21093488 PMID21093488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21093488/
RECORD: Rec_0252506 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Aedes albopictus C6/36 cells
PMID23226444 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226444/
RECORD: Rec_0257724 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Fusion inhibition
Dengue virus (DENV) | epithelial cells
10 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses. | da Silva-Júnior EF, de Araújo-Júnior JX. | Bioorg Med Chem. 2019 Sep 15;27(18):3963-3978. | DOI:10.1016/j.bmc.2019.07.038 | PMID:31351847 PMID31351847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31351847/
RECORD: Rec_0260202 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Russian spring-summer encephalitis virus (RSSEV)
PMID23226444 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226444/
RECORD: Rec_0262604 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
West Nile virus(WNV)
PMID31351847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31351847/
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