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MYP_091100
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Basic Information
DENV-2 gp (412-444), DN59
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition ▸ Release inhibitor
Antiviral ▸ Virucidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
33 amino acids
C161H240N38O44S
Standard
Sequence
MAILGDTAWDFGSLGGVFTSIGKALHQVFGAIY
Physicochemical Analysis
3443.92 Da
5.19
-1.41
-1.68
-0.0428
0.78
0.61
0.46
8.74
100.61
0.1515
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1283.85
-9.42
45.0
45.0
109.0
244.0
7.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0096354 VERIFIED: YES
Provenance & Taxonomy
Dengue virus 2 [Virus]
Virus-derived peptide
11060;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal Release inhibitor
Dengue 2 virus (Virucidal); LLC-MK2
2-5 μM
Focus reduction assay
PaperRelease of dengue virus genome induced by a peptide inhibitor. | Lok SM, Costin JM, Hrobowski YM, Hoffmann AR, Rowe DK, Kukkaro P, Holdaway H, Chipman P, Fontaine KA, Holbrook MR, Garry RF, Kostyuchenko V, Wimley WC, Isern S, Rossmann MG, Michael SF. | PLoS One. 2012 | PMID:23226444 PMID23226444 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226444/
RECORD: Rec_0098777 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
West Nile virus (Virus entry); LLC-MK2
93 %
Plaque assay
PaperPeptide inhibitors of dengue virus and West Nile virus infectivity. | Hrobowski YM, Garry RF, Michael SF. | Virol J. 2005 | PMID:15927084 PMID15927084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15927084/
RECORD: Rec_0108768 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Monkey kidney epithelial cells LLC-MK2 ( at NA
Hemolysis
PMID23226444 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226444/
RECORD: Rec_0123333 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-2
PMID23226444 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226444/
RECORD: Rec_0190007 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Yellow fever virus (YFV)
PMID23226444 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226444/
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