Peptide Database

Peptide NameSLAY-screened peptide P4543

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC73H108N20O19S

DescriptionStandard

        ATCWHPLRPSVFTS
    

Molecular Weight1601.83 Da

Isoelectric Point (pI)8.30

Net Charge (pH 7.0)0.87

Net Charge (pH 7.4) 0.62

Charge Density (pH 7.0) 0.0624

GRAVY Index0.02

Hydrophobic Moment 0.27

Boman Index0.14

Instability Index82.33

Aliphatic Index 55.71

Aromaticity 0.1429

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 611.33

LogP -5.69

H-bond Donors 23.0

H-bond Acceptors 22.0

Rotatable Bonds 43.0

Heavy Atoms 113.0

Ring Count 6.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0381331 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/