Peptide Database

Peptide NameWNV(1965-1972)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus

Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Helicase inhibition

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC34H57N13O14

DescriptionStandard

        RNPSQVGD
    

Molecular Weight871.89 Da

Isoelectric Point (pI)6.09

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0295

GRAVY Index-1.70

Hydrophobic Moment 0.65

Boman Index-0.45

Instability Index48.69

Aliphatic Index 36.25

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 463.84

LogP -7.54

H-bond Donors 15.0

H-bond Acceptors 14.0

Rotatable Bonds 27.0

Heavy Atoms 61.0

Ring Count 1.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0358213 VERIFIED: YES

Provenance & Taxonomy

OrganismWest Nile virus [Virus]

FamilyVirus-derived peptide

Tax ID11082;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Replication inhibitor

TargetWest Nile virus (Replication); Vero

Activity383 μM

MethodHelicase assay

PaperViral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). | Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A. | Biochem Pharmacol. 2008 | PMID:18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/

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